I'm trying to enable twilio. Whenever I enter the Application Configuration all the properties are "greyed" out. I can copy and create a non-OEM twilioenable and modify it but I cannot modify the OEM property.

Anyone have any idea why?

Those are based on the VTScada default OEM layer properties and can't be edited in your application. If you duplicate a property then your new Application property will override the OEM Layer property but should your property be removed, the existing property value will be used.